By Dr. McKenzie Nisbet, ND

Menopause: The Basics

MENOPAUSE: THE BASICS

Millions of women experience menopausal symptoms each year, however there is often confusion over when menopause starts, what’s happening below the surface and what options we have for testing and treatment. Let’s start by defining a few terms.

DEFINING THE TERMS

PREMENOPAUSE starts at puberty and continues into your 40s (typically). During this time, you (should) have regular cycles.

PERIMENOPAUSE marks the time before menopause when hormones are shifting. This typically occurs in your 40s and 50s and symptoms often start here.

MENOPAUSE is reached after 12 consecutive months with no period. Symptoms can carry through peri-menopause into menopause.

THE HORMONAL SHIFT

During perimenopause hormones such as progesterone, estrogen and testosterone decline.

PROGESTERONE is ONLY produced when we ovulate. In a perfect world this happens predictably once each month. During perimenopause women ovulate less consistently and our cycles become less predictable. No ovulation means no progesterone spike. Less progesterone can trigger issues such as insomnia and feelings of anxiety due to less GABA receptor simulation.

ESTROGEN levels gradually decline during this time as well. This decline can be at an irregular pace, which is why symptoms can vary. The reduction in estrogen increases the risk for osteoporosis and cardiovascular disease and can trigger vasomotor symptoms such as hot flashes and night sweats, brain fog and vaginal dryness.

TESTOSTERONE naturally declines as we age. Testosterone peaks in our 20s and continues to decline through perimenopause and menopause. Proper sleep and resistance training are important to support hormone production.

This hormonal shift can be unpredictable. Some days or months can be good and some days or months can be full of symptoms. For some women this transition is easy for others it’s a roller coaster ride of symptoms including:

  • Hot Flashes
  • Night Sweats
  • Irregular Cycles
    • Heavier or Lighter Periods
    • Longer or Shorter Cycles
    • Increased or Decreased Cramping
    • Increased or Decreased PMS
  • Insomnia
  • Weight Gain
  • Anxiety
  • Depression
  • Migraines
  • Vaginal Dryness
  • Reduced Libido

If you are one of the lucky ones with a smooth transition – fantastic. If you are one of the many facing these symptoms – get to know your testing and treatment options.

INVESTIGATING YOUR TRANSITION

Every woman presents with difference symptoms. Knowing your numbers helps create a more targeted treatment plan.

TRACKING. Track your symptoms. These can vary day to day and month to month. Monitoring the number of hot flashes, severity of night sweats, sleep changes, cycles, etc. can help us understand your unique picture.

COMPREHENSIVE TESTING. The DUTCH test is my favourite for getting an overall picture of your sex hormones and adrenal function.

BLOOD WORK. Depending on your specific symptoms, we can use different blood parameters to uncover imbalances and deficiencies. Here are some of the parameters I commonly run with my peri-menopausal patients:

  • Thyroid Panel (TSH, Free T3, Free T4, Anti-TPO, Anti-TG). Often run when symptoms of under-active thyroid are present (fatigue, dry skin, hair loss, etc), or when weight is a major concern.
  • Insulin, Glucose and Leptin. These parameters are used to determine if there is an underlying insulin resistance or leptin resistance contributing to weight gain.
  • Vitamin B12 and Iron. These are commonly used when fatigue is a major concern, when there is abnormal bleeding, or when thyroid concerns are present.
  • Vitamin D. Risk of osteoporosis increases with menopause due to the reduction in estrogen levels. We want to ensure adequate Vitamin D levels are maintained to support bone health.
  • Cholesterol and HbA1c. Lipid levels can shift during peri-menopause. Running a full lipid panel and HbA1c (blood sugar) lets us monitor for any unwanted increases/declines. We can then intervene with diet, lifestyle or supplement support as needed.

TREATMENT OPTIONS

It is important to remember that what was working for you at 20 or 30 may no longer be working at 40 or 50. Adjustments to diet and lifestyle are often needed as we enter this transition.

Depending on your symptoms experience and lab results we can create a treatment plan unique to your goals. Treatment can include dietary and lifestyle changes, nutraceuticals, herbal medicine (to support thyroid, adrenal and sex hormones), and/or bio-identical hormone therapy (BHRT) such as topical progesterone cream.

Get to know your options. Schedule your Free 15-Minute Meet & Greet here and lets chat!

By Dr. McKenzie Nisbet, ND

Body Fat & Blood Sugar

 

BODY FAT & BLOOD SUGAR

 

Weight gain and stubborn weight loss are common concerns in my practice. Poor dietary habits, sedentary lifestyles, nutrient deficiencies, under-active thyroid glands, hormone imbalances, blood sugar imbalances and insulin resistance are some of the many areas we address to promote sustainable weight loss. The latter two are especially common. Gaining control of your blood sugar and optimizing your insulin levels may be the missing piece of your puzzle to achieve balance and weight loss.

 

WHY DOES INSULIN RESISTANCE MATTER? 

Blood sugar imbalances and insulin resistance promote lipogenesis – fat storage. This means weight gain, which is linked to serious conditions such as type 2 diabetes, increased stroke risk, high blood pressure, high cholesterol, cardiovascular disease, Alzheimer’s, non-alcoholic fatty liver disease, sleep apnea, gallbladder disease, and polycystic ovarian syndrome (PCOS).

By stabilizing your blood sugar and re-sensitizing your cells to insulin you can stop the weight gain, promote weight loss and mitigate the conditions listed above. But there is no need to wait until a formal diagnosis is made to take action. In fact, insulin resistance and blood sugar imbalances often show up 10-20 years before a formal disease diagnosis is made. Take note of the signs of insulin resistance and start your prevention strategy now. Conditions like diabetes don’t show up overnight. The food you eat, your perception of stressors, how you spend your spare time, etc. will all either help or hinder your health. It is what you do daily matters. So, don’t wait for the diagnosis – start to identify signs and symptoms of insulin resistance and intervene early to help prevent the onset of disease and disability.

 

SIGNS & SYMPTOMS

  • Abdominal (visceral) fat
  • Difficulty losing weight
  • Cravings for carbohydrates or sugar
  • Fluid Retention & Bloating
  • Fatigue & Tiredness
  • Brain Fog & Poor Concentration
  • Headaches
  • Mood Swings, Anxiety & Irritability
  • Weakness
  • Insomnia
  • Dyslipidemia, such as increased cholesterol
  • Abnormal blood parameters, such as elevated CRP, hs-CRP, and ESR
  • Sleep-disordered breathing (sleep apnea)
  • Hormone dysregulation, such as PCOS (Anovulatory Androgen Dominance)

 

HOW DOES INSULIN RESISTANCE OCCUR?

When we eat, our blood glucose (blood sugar) levels rise which causes our pancreas to release insulin into the blood stream. Insulin’s job is to tell fat and muscle cells to absorb the glucose from the bloodstream. Any excess glucose gets stored in the liver as glycogen, which can be broken down into glucose when needed. This absorption causes the blood glucose levels to fall back to a normal level.

When we are insulin resistant, our fat, muscle and liver cells are less receptive to insulin. Therefore, more insulin is needed to persuade these cells to absorb glucose from the bloodstream. Our pancreas responds to the heightened blood glucose levels by producing more insulin (causing elevated insulin levels). Overtime the pancreas is unable to keep up with the demand for insulin and so glucose levels remain elevated in our blood stream. This high blood glucose result in pre-diabetes and eventually, type 2 diabetes.

 

HOW DO YOU STABILIZE BLOOD SUAGR & REVERSE INSULIN RESISTANCE?

The good news is there is so much you can do to reverse blood sugar imbalances and insulin resistance. This can be done via sustainable diet and lifestyle changes as well as supplementation to help give you a kick start!           

 

DIETARY MODIFICATIONS

Dietary changes such as avoiding processed foods, refined sugars, simple carbohydrates, and foods with a high glycemic index are a great place to start. Work on replacing these foods with a diet rich in whole foods, protein, fibre, healthy fats and vegetables! Following a Mediterranean diet, ketogenic or ketogenic-like diet, Whole 30 diet, or AIP (autoimmune paleo) diet can be helpful if you prefer a more structured approach to dietary changes. Intermittent fasting has also been shown to improve glucose and insulin parameters. Talk to your nutritionist or Naturopathic Doctor to determine the right approach for you! If you are type 1 diabetic or on blood glucose modulating / diabetic medication be sure to check with your medical or naturopathic medical doctor before making any major dietary or lifestyle changes.

 

NUTRACEUTICALS & BOTANICAL MEDICINE

Utilizing supplements along with dietary and lifestyle modification is a great way to improve your blood glucose and insulin levels. However, there are many products on the market promising to reverse diabetes or help you shed extra pounds that don’t actually have the research to back up their claims. When choosing to supplement you need to ensure it is the right substance, at the right dose and the right time. Your supplements should also be processed properly, be in the correct form to improve absorption (ie. capsule, tablet, liquid, powder, etc), not include any fillers or dyes, and be selected based on your specific needs.

Nutrients such as chromium picolinate and inositol have been shown to help improve insulin sensitivity. Myo- and d-chiro- inositol in particular, have been shown to mimic insulin and reduce postprandial glucose levels (reduce the spike in blood sugar after eating). Botanicals such as Vaccinium (Blueberry), Trigonella foenum-graecum (fenugreek), Ocimum santum (Holy basil), Cinnamomum spp.(Cinnamon) and Gymnema sylvestre (Gymnema) have all shown to be effective at blood sugar balancing. Gymnema, for example, has been shown to help control sugar cravings, modulate insulin secretion from the pancreas and reduce absorption of sugar molecules in the intestine, therefore reducing blood sugar.

It is a common misconception that “natural” is equivalent with “safe”. If you are considering approaching your blood sugar imbalances or insulin resistance from a more natural approach be sure to work closely with a Naturopathic Doctor. This is especially important if you are currently on medication or have a formal diabetes diagnosis.

Want to learn more? Set up a free 15-minute meet and greet appointment and let’s chat!

 

      https://www.ncbi.nlm.nih.gov/pubmed/2240915/,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1204764/, https://www.ncbi.nlm.nih.gov/pubmed/6836034,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912882/, https://www.ncbi.nlm.nih.gov/pubmed/19761040,https://www.ncbi.nlm.nih.gov/pubmed/15487760,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078644/,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027050/

By Dr. McKenzie Nisbet, ND

What is PCOS? (and Why It Needs a New Name)

WHAT IS PCOS? (and Why It Needs a New Name)

 

PCOS is Polycystic Ovarian Syndrome and affects around 1 in 10 women of reproductive age.

The hallmarks of PCOS are anovulation (lack of ovulation) and high levels of androgens (such as testosterone). The signs and symptoms of PCOS can vary woman to woman and include: anovulation (determined by tracking your cycle), amenorrhea (no period), irregular periods, hirsutism (excess facial hair), acne, hair loss, weight gain, and/or infertility.

 

To be diagnosed with PCOS you must meet a set of criteria. The two main ones are the: “Rotterdam Criteria” and “Androgen Excess Society Criteria.” I prefer the “Androgen Excess Society Criteria” because it emphasizes the importance of anovulation and androgen excess.

The Rotterdam criteria does not require androgen excess and instead puts equal emphasis on “polycystic ovaries”. You may be asking: Why is this an issue? The name is “polycystic ovarian” syndrome? Shouldn’t that be a key player in diagnosing PCOS? This is why PCOS needs a new name.

Polycystic ovaries are not specific to women with PCOS. Polycystic ovaries are a normal finding in 23% of women (reporting no menstrual irregularities, no infertility, and no abnormal hair growth). Whether or not you have polycystic ovaries, cannot rule in or out PCOS. Therefore a name such as ‘Anovulatory Androgen Excess’ would be much more appropriate.

 

If you think you have PCOS, it is important that a proper diagnosis is made. If you have been diagnosed with PCOS only based on the results of a ultrasound talk to your healthcare provider about being reassessed. This involves a thorough evaluation of your menstrual cycle, acne, weight, and hair growth, as well as comprehensive laboratory testing (including androgens).

Based on your individual presentation of PCOS a unique treatment plan can then be created. In general, this involves addressing one (or more) of the four main drivers of PCOS: insulin resistance, a hormonal imbalance from stopping the birth control pill, inflammation, or adrenal abnormalities.

 

Questions? Send me a message here or book a free 15-minute discovery session here.

 

References:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563096/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872139/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1069067/
Menopause: The Basics
Body Fat & Blood Sugar
What is PCOS? (and Why It Needs a New Name)